DNA Methylation & DunedinPACE Decoded

Chronological Time Is Fixed. Biological Velocity Is Not.

How fast are your organs aging relative to the calendar? Simulate your DunedinPACE biological pace of aging and discover how minor epigenetic adjustments compound into decades of vital healthspan.

What is the DunedinPACE epigenetic pace of aging? Developed by researchers at Duke and Columbia University, DunedinPACE is a 3rd-generation DNA methylation clock that measures your current rate of biological aging (e.g., 0.79 biological years per calendar year vs. 1.20). Unlike static chronological age, this speed is modifiable through targeted functional medicine, metabolic sequencing, and zone 2 training.
Interactive DNA Methylation Projection

Optimized Longevity Protocol

Active metabolic sequencing, optimal deep sleep, and Zone 2 cardiorespiratory training.

Current Pace of Aging 0.78 yrs / calendar yr
48 Years Old
0.78 yrs/yr
15 Years Forward
5 Yrs10 Yrs15 Yrs20 Yrs25 Yrs
🧬 Future Biological Age
59.7 Yrs

vs 63.0 Calendar Yrs

⚡ Biological Advantage
-3.3 Years

Biological age reduction achieved

⏳ Healthspan Horizon
+8.2 Years

Of disease-free vitality preserved

🛡️ Chronic Risk Modulation
-42% Risk

Reduced cumulative all-cause mortality hazard

The 5 Core Epigenetic Levers Guided by Integrix

01. Methylation

DNA Methylation Integrity

Optimizing methyl donor availability (SAMe, active B12, folate, betaine) guided by 3X4 genomic methylation pathways to maintain chromatin stability.

02. Metabolism

Insulin & Glycemic Flux

Maintaining fasting insulin < 5.0 µIU/mL to activate cellular AMPK, promote autophagy, and eliminate advanced glycation end-products (AGEs).

03. Mitochondria

Zone 2 Mitochondrial Density

Targeted lactate clearance training to expand mitochondrial volume, enhance fatty acid oxidation, and elevate maximal oxygen uptake (VO2 max).

04. Autonomic

Deep Sleep & Glymphatic Flush

Maximizing slow-wave sleep architecture and nighttime HRV recovery to drive brain glymphatic clearance and cellular repair.

Measure your epigenetic pace of aging with objective precision.

TruAge DNA methylation analysis and 3X4 genetic testing are integrated into Rung 4 (Longevity by Design). Schedule a free 30-minute discovery session with Dr. Paul M. Bekkum, DC, CCEP.

Schedule Your Free Discovery Session Explore Longevity Roadmap